With Ventoy, you don't need to format the disk over and over, you just need to copy the ISO/WIM/IMG/VHD(x)/EFI files to the USB drive and boot them directly. You can copy many files at a time and Ventoy will give you a boot menu to select them. Can be installed on USB/Local Disk/SSD/NVMe/SD Card.
x86 Legacy BIOS, IA32 UEFI, x86_64 UEFI, ARM64 UEFI and MIPS64EL UEFI are supported in the same way. Most type of OS supported (Windows/WinPE/Linux/ChromeOS/Unix/VMware/Xen...).
So if a new distro or even existing version update happens, it's just a matter of copying the new ISO or image file over to the USB drive. No need to reformat an image file to the drive.
For persistence, you have no need to create any separate partition, and no need to add a persistent boot parameter. Just put a persistence data file in the 1st partition and tell Ventoy by the json configuration, and that's it. You can specify more than one data file to an ISO file, and Ventoy will provide a menu to choose before booting.